Xifaxan is a rifamycin which works by killing bacteria that causes infection. The most common form of Xifaxan is a 550mg tablet. It is also available as a 200mg tablet. There are currently no generic alternatives for Xifaxan. It is covered by some Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Compare generic Xifaxan (rifaximin) prices from accredited international online pharmacies, U.S. mail-order pharmacies, and discount coupon programs. The lowest available price for generic Xifaxan (rifaximin) 550 mg is $0.61 per tablet for 200 tablets at PharmacyChecker-accredited online pharmacies. Compare Xifaxan prices at 60,000+ US pharmacies. Get a free Rx.com coupon and save up to 90% on your prescription. Compare Xifaxan prices, print discount coupons, find manufacturer promotions, copay cards and patient assistance programs. Get the facts on cost and Xifaxan, how the generic compares with the brand name, what financial assistance may be available, and more. Get the best price on Xifaxan at pharmacies near you with SingleCare. Save up to 80% with our Xifaxan coupons – with or without insurance! Xifaxan and its generic can be purchased at a lower cost from pharmacies in Canada and other countries. People can easily save money on Xifaxan 550 mg by comparing Xifaxan prices at Canadian and international online pharmacies. Wondering when a generic version of Xifaxan will be available? Get details on FDA approval status, generic manufacturers, and patent expirations. Transfer your prescription for XIFAXAN 550 MG TAB on Amazon Pharmacy. FREE SHIPPING for Prime members. How much does Xifaxan cost without insurance? The lowest listed cash price we found for Xifaxan 550 mg (60 ct) is $3839.09 at BetterBuy Rx, based on 1 pharmacy listing checked October 19, 2026. The total cost of treatment without insurance could range from $421 (three days) to thousands of dollars (for longer treatments). Generic Xifaxan (rifaximin) is not yet available in the United States. A manufacturer's savings card or patient assistance program may help lower the cost of Xifaxan for eligible patients. Learn about Xifaxan (rifaximin) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. By choosing generic Rifaximin, patients can save over 90% compared to the retail price of Xifaxan. This makes it a highly cost-effective alternative for those requiring long-term treatment or repeated courses of the medication. Frequently Asked Questions about Xifaxan 1. Is Xifaxan covered by insurance? Yes, Xifaxan is covered by most health insurance plans, including Medicare and Medicaid … Compare generic Xifaxan (rifaximin) prices from accredited international online pharmacies, U.S. mail-order pharmacies, and discount coupon programs. The lowest available price for generic Xifaxan (rifaximin) 550 mg is $0.61 per tablet for 200 tablets at PharmacyChecker-accredited online pharmacies. Xifaxan (rifaximin) Savings – ordering the generic from abroad With Xifaxan projected to enjoy patent protection until 2029, cost relief through generic competition isn't exactly around the corner domestically. Xifaxan is a prescription drug used to treat some types of diarrhea and certain other conditions. Learn about the drug's cost, how to find savings, and more. Find information about patient assistance and insurance coverage for Xifaxan for adults with Overt Hepatic Encephalopathy. See Safety and Full Prescribing Information. Medicare coverage and pricing details for Xifaxan. Learn more about Medicare prescription drug plans and savings with GoodRx. Xifaxan (generic name rifaximin) is an antibiotic primarily used for treating irritable bowel syndrome (IBS), travelers' diarrhea, and hepatic encephalopathy. It's proven to be a preferred option for many, thanks in large part to its localized mechanism of action in the gut and fewer systemic side effects compared to other antibiotics. However, Xifaxan costs can be prohibitive for some … Xifaxan in 2026 too expensive? Find manufacturer coupons, pharmacy discounts, generic options, and the best prices at pharmacies near you on Medfinder. Learn about XIFAXAN, a treatment for the reduction in risk of Overt HE recurrence in adults. Please see Important Safety Information and full Prescribing Information for XIFAXAN. Generic medications may be manufactured by different companies. This means some generics vary in size, color, and shape. But the active ingredients are always the same. Amazon Pharmacy uses different manufacturers to ensure medication supply and offer low prices for our customers. Checking your browser before accessing pmc.ncbi.nlm.nih.gov … Why is Xifaxan so expensive? Xifaxan (rifaximin) is a brand-name drug manufactured by Salix Pharmaceuticals. It is an effective treatment option for irritable bowel syndrome with diarrhea (IBS-D), traveler's diarrhea, and hepatic encephalopathy. U.S. Retail Prices for Xifaxan (Rifaximin) Retail pharmacy prices remain high for Xifaxan (Rifaximin). Based on recent April 2025 data, the average cost for a 30-day supply at major local pharmacies includes: Jewel-Osco: $1,582.00 Walgreens: $1,782.00 Walmart: $1,803.00 Target: $1,729.00 Meijer: $1,668.00 Ready to purchase your medication for up to 80% off? Visit Planet Drugs Direct. Many Americans choose to buy generic rifaximin from Canada because it is significantly cheaper than brand-name Xifaxan sold at U.S. retail pharmacies. With a valid prescription, Americans can order generic rifaximin from Canadian pharmacies and often pay a much lower price per tablet. Xifaxan vs rifaximin generic cost (550 mg) Although it's an effective and well-tolerated drug, it may be more costly than alternatives since there's no generic available. A Xifaxan savings card from SingleCare can help lower the cost of this medication regardless of insurance coverage. How much does Xifaxan cost? The average retail price of Xifaxan is $461 per 6, 550 mg tablets. XIFAXAN (rifaximin) is an antibiotic used to treat hepatic encephalopathy (HE) and traveler's diarrhea. Its market trajectory is influenced by patent expiries, generic competition, and evolving treatment guidelines. What is the Current Market Status of XIFAXAN? Canadian pharmacy, generic rifaximin: Offers the same active ingredient as brand-name Xifaxan at a much lower cost. Generic rifaximin is available in Canada but not yet available in the United States, giving patients an additional lower-cost option. Rifaximin (Zaxine): For the Reduction in Risk of Overt Hepatic Encephalopathy (HE) Recurrence in Patients ≥ 18 Years of Age [Internet]. Show details Save on Rifaximin in 2026: compare pharmacy prices, find coupons, and discover discount programs. Medfinder helps you find the lowest price near you. Buy Xifaxan online and check Xifaxan generic, price, and cost for digestive infection and gut health treatment. Xifaxan is prescribed to treat certain types of diarrhea and to lower the risk of a brain condition in adults with severe liver disease. It's a brand-name drug, available as the generic medication rifaximin. It comes as an oral tablet. The cost with or without insurance can depend on several factors. It might be lowered by using a coupon. Compare the cost of prescription and generic Rifamycins medications. See information about popular Rifamycins, including the conditions they treat and alternatives available with or without insurance. Xifaxan is a brand-name drug, which means there is no widely available generic version in the United States at this time. Brand-name status often keeps prices high due to research, patent protection, and market exclusivity. Treatment of irritable bowel syndrome with diarrhea (IBS-D). To lower the risk of hepatic encephalopathy, a brain condition caused by severe liver disease. Compare Xifaxan prices and find coupons that could save you up to 80% instantly at pharmacies near you such as CVS, Walgreens, Walmart, and many more. Learn more about Xifaxan pricing, uses, and interactions. WellRx helps you find the cheapest pharmacy deals and drug savings. Get a rifaximin (generic Xifaxan) prescription online for bacterial infections available with same-day local pickup near you. Get the best price on Rifaximin at pharmacies near you with SingleCare. Save up to 80% with our Rifaximin coupons – with or without insurance! Find the lowest prices for Xifaxan at pharmacies near you. Get free RxSaver coupons and save up to 80% on your prescription.