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Includes Xifaxan side effects, interactions and indications. Find resources about Xifaxan for your practice and to help patients with IBS-D to understand treatment and symptoms. See Safety and Full Prescribing Information. Xifaxan (rifaximin) is a brand-name oral tablet used for diarrhea and hepatic encephalopathy in certain situations. Learn about dosage, side effects, and more. Transfer your prescription for XIFAXAN 550 MG TAB on Amazon Pharmacy. FREE SHIPPING for Prime members. Rifaximin (Xifaxan) treats diarrhea caused by traveling or irritable bowel syndrome. It can also prevent hepatic encephalopathy. Xifaxan is a prescription drug used to treat some types of diarrhea and certain other conditions. Learn about the drug's cost, how to find savings, and more. XIFAXAN is a prescription antibiotic that works mainly in the digestive tract. XIFAXAN 550-mg tablets are indicated for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in adults. 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