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Tell your doctor if you have … Pristiq (desvenlafaxine) is a brand-name prescription drug that's used to treat depression in adults. Learn about side effects, warnings, dosage, and more. Medscape – Major depressive disorder dosing for Pristiq (desvenlafaxine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Pristiq is an antidepressant used off-label for treating anxiety and panic disorders, but it is FDA-approved only for major depressive disorder. Common side effects of Pristiq include dizziness, nausea, insomnia, and sexual dysfunction, which often improve within a couple of weeks. Pristiq carries a risk of increased suicidal thoughts in young people, requiring close monitoring. These highlights do not include all the information needed to use PRISTIQ safely and effectively. See full prescribing information for PRISTIQ. PRISTIQ® (desvenlafaxine) Extended-Release Tablets … Desvenlafaxine, also known as the brand name Pristiq, is a medication used to treat depression in adults. It belongs to a drug class called serotonin and norepinephrine reuptake inhibitors (SNRIs). Desvenlafaxine (Pristiq) comes as a tablet that's taken by mouth once a day. Some side effects include nausea, dry mouth, and dizziness. It can also make you feel sleepy or cause trouble sleeping. Generic name: desvenlafaxine (des ven la FAX een) Tablets (extended release): 25 mg, 50 mg, 100 mg Brand name: Pristiq® Tablets (extended release): 25 mg, 50 mg, 100 mg All FDA black box warnings are at the end of this fact sheet. Please consult them before taking this medication. What Is Desvenlafaxine And What Does It Treat? 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