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Bactrim is a prescription drug used to prevent and treat various infections. Learn about the drug's cost, how to find savings, and more. Transfer your prescription for SULFAMETHOXAZOLE – TRIMETHOPRIM DS 800 MG – 160 MG TAB on Amazon Pharmacy. FREE SHIPPING for Prime members. FIND YOUR SAVINGS Sulfamethoxazole-Trimethoprim Coupon (Generic for Bactrim) Pricing is displayed for SULFAMETHOXAZOLE-TRIMETHOPRIM, which is a less expensive option of BACTRIM. This medication is a combination of two antibiotics: sulfamethoxazole and trimethoprim. It is used to treat a wide variety of bacterial infections. It is also used to prevent and treat a certain type of pneumonia (pneumocystis-type). This medication treats only certain types of infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not … Sulfamethoxazole is a sulfonamide, or "sulfa" drug, while trimethoprim is a unique antibiotic related to the cancer drug methotrexate. 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