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(4.1) For some drugs, competition for CYP3A by efavirenz could result in inhibition of their metabolism and create the potential for serious and/or life-threatening adverse reactions (eg … Efavirenz works with other medication to treat HIV. HIV slowly weakens your immune system. You can take this capsule by mouth as directed. Find patient medical information for Efavirenz (Sustiva) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Save more on your prescription medication with sustiva coupons. Get your own, free sustiva discount card on rxless.com. Sustiva and its Availability Over the Counter When it comes to the availability of Sustiva, it is important to note that this antiviral medication is not available over the counter and requires a prescription from a healthcare professional. Buy Sustiva, Generic Efavirenz and Canada prescription drugs from our generic pharmacy Blue Sky. 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